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SeqOccIn: expertise in sequencing of long DNA fragments

The SeqOccIn (Sequencing Occitanie Innovation) project, supported by Genotoul's INRA platforms GeT-PlaGe (Genome and Transcriptome platform) and Bioinfo (Bioinformatics Platform), has been selected by the Occitanie Region for ERDF funding. This project, which also involves 4 INRA laboratories and 14 companies, is mainly oriented towards the development of advanced expertise in the use of different sequencing technologies, particularly those allowing the sequencing of long DNA fragments into single molecules.

Updated on 04/15/2019
Published on 04/15/2019

The Sequençage Occitanie Innovation (SeqOccIn) project aims to acquire advanced expertise of single molecule long fragment sequencing technologies in three fields of study: genome polymorphism (source of genetic diversity), epigenome (partially reversible marks carried by DNA modifying gene expression without changing DNA), metagenome (communities including bacteria present in a complex environment such as the intestine, faeces, food, etc.).

It will allow both sequencing and bioinformatics platforms to deepen their expertise on the optimal combination of short and long fragment technologies for different genome knowledge objectives ranging from diversity detection to the production of a complete sequence of an individual's genome. The analysis of native DNA molecules will also allow the detection of certain epigenetic marks. Finally, the study of long DNA fragments will make it easier to identify the bacterial populations present in a sample and to study bacterial communities. 

Supported by the 2 Toulouse platforms, the project, with a total budget of €6 million, has attracted the interest of 14 companies that have joined forces to co-finance this project. The following are partners in the project:

  • Apis Gene bringing together 8 companies from the world of bovine and caprine breeding (Auriva, Evolution, Gene Diffusion, Créalim, Umotest, BGS, Elitest and Capgenes),
  • Alliance R&D bringing together the 3 pig breeders (Axiom, Nucleus and Choice Genetics),
  • the CNBL and the SYSAAF for sheep and poultry breeding,
  • Lallemand and Adisseo for animal nutrition,
  • Limagrain, Euralis, RAGT, Syngenta, Maïsadour, Caussade Semences and KWS, partners of the Amaizing Future Investment Project, for corn selection,
  • Adelis/Picometrics for the development of DNA preparation instruments.

For each of the species concerned, the project brings together public and private research stakeholders to make the most of the expertise acquired and the data produced by the project, taking into account the common or specific objectives of each. The SeqOccIn project will also finance developments on data analysis through the mobilization of researchers from the Toulouse MIAT (Mathematics and Applied Informatics of Toulouse) and GenPhySE (Genetics, Physiology and Livestock Systems) units in addition to engineers from the 2 platforms or the SIGENAE team at GenPhySE.

Over a period of 3 years, the project will finance in particular a team of a dozen people and the acquisition of expertise through the production and analysis of data sets of interest to all partners. 

The kick off meeting of the SeqOccIn project will take place on April 18.

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